Target trial emulation of aspirin after diagnosis of colorectal polyps.

ABSTRACT:

Backgound and aims

Previous research on the potential chemoprotective effect of aspirin for colorectal cancer (CRC) shows conflicting results. We aimed to emulate a trial of aspirin intiation in individuals with incident polyps.

Methods

We identified individuals registered with their first colorectal polyp in the nationwide gastrointestinal ESPRESSO histopathology cohort in Sweden. Individuals aged 45-79 years diagnosed with colorectal polyps 2006-2016 in Sweden without CRC or contraindications for preventive aspirin (cerebrovascular disease, heart failure, aortic aneurysms, pulmonary emboli, myocardial infarction, gastric ulcer, dementia, liver cirrhosis, or any other metastatic cancer) registered until the month of first polyp detection were eligible. Using duplication and

SUBMITTER: Emilsson L 

PROVIDER: S-EPMC10570175 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature