Mitochondrial DNA Copy Number, a Damage-Associated Molecular Pattern Molecule, Can Predict Pancreatic Necrosis and Is Correlated with the Severity of Acute Pancreatitis.

ABSTRACT:

Background

Mitochondrial DNA (mtDNA) is a damage-associated molecular pattern molecule that can trigger an immune-inflammatory response during pancreatic necrosis (PN).

Aim

To evaluate the role of mtDNA in the detection of PN and severe acute pancreatitis (SAP).

Methods

The present study included 40 AP patients and 30 controls. AP patients were grouped into mild AP (MAP, n = 15), moderately severe AP (MSAP, n = 17), and SAP (n = 8). Also, the SAP + MSAP group, n = 25, was compared to MAP. AP patients were divided into NAP (n = 7) and non-necrotizing AP (n = 33). The mtDNA copy number, IL-6, and STAT3 expression levels were measured using quantitative real-time PCR.

Results

The mtDNA, IL-6, and STAT3 levels were significantly higher in AP patients than in contro

SUBMITTER: Ezzat GM 

PROVIDER: S-EPMC10570179 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature