Conventional and genetic associations of adiposity with 1463 proteins in relatively lean Chinese adults.

ABSTRACT: Adiposity is associated with multiple diseases and traits, but little is known about the causal relevance and mechanisms underlying these associations. Large-scale proteomic profiling, especially when integrated with genetic data, can clarify mechanisms linking adiposity with disease outcomes. We examined the associations of adiposity with plasma levels of 1463 proteins in 3977 Chinese adults, using measured and genetically-instrumented BMI. We further used two-sample bi-directional MR analyses to assess if certain proteins influenced adiposity, along with other (e.g. enrichment) analyses to clarify possible mechanisms underlying the observed associations. Overall, the mean (SD) baseline BMI was 23.9 (3.3) kg/m², with only 6% being obese (i.e. BMI ≥ 30 kg/m²). Measure

SUBMITTER: Yao P 

PROVIDER: S-EPMC10570181 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature