Causal link between thyroid function and schizophrenia: a two-sample Mendelian randomization study.

ABSTRACT: Schizophrenia is a chronic psychiatric disorder with inconsistent behavioral and cognitive abnormalities with profound effects on the individual and the society. Individuals with schizophrenia have altered thyroid function, but results from observational studies are conflicting. To date, it remains unclear whether and in which direction there is a causal relationship between thyroid function and schizophrenia. To investigate causal paths, a bidirectional two-sample Mendelian randomization (MR) study was conducted using summary statistics from genome-wide association studies including up to 330,132 Europeans. Thyroid function was described by the normal-range thyroid-stimulating hormone (TSH) and free thyroxine levels as well as an increased and decreased TSH status. The iterative radial in

SUBMITTER: Freuer D 

PROVIDER: S-EPMC10570193 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature