Phylogenetic analysis of prospective M. bovis antigens with the aim of developing candidate vaccines for bovine tuberculosis.

ABSTRACT:

Background

Bovine Tuberculosis is a respiratory disease caused by the pathogen Mycobacterium bovis (M. bovis) that infects cattle. Though rare, this disease can also affect humans, as well as domestic and wild animals, making it a serious concern. Therefore, searching for alternative and new vaccines with high efficiency and safety is the main goal in bovine tuberculosis prophylaxis. New vaccines, known as vector vaccines, have the potential to become safe and effective alternatives to the traditional BCG vaccine. In this study, two major immunodominant proteins of M. bovis Esat-6 and TB10.4 were utilized to create a vector vaccine for bovine tuberculosis.

Methods

The Esat-6 and TB10.4 genes were amplified by PCR. The amplified and purified PCR products were sequenced by the

SUBMITTER: Abay Z 

PROVIDER: S-EPMC10570230 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature