The influence of sex difference on behavior and adult hippocampal neurogenesis in C57BL/6 mice.

ABSTRACT: Animal models have been used extensively in in vivo studies, especially within the biomedical field. Traditionally, single-sex studies, mostly males, are used to avoid any potential confounding variation caused by sex difference and the female estrous cycle. Historically, female animal subjects are believed to exhibit higher variability, and this could increase the statistical power needed to test a hypothesis. This study sets out to evaluate whether a sex difference does exist in mouse behavior, and whether female mice featured higher variability. We assessed the sensorimotor skills, anxiety-like behavior, depression-like behavior, and cognitive abilities of mice through a series of commonly used behavioral tests. Except for the stronger grip force and lower tactile sensory sensitivity de

SUBMITTER: Tsao CH 

PROVIDER: S-EPMC10570284 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature