ZSP1601, a novel pan-phosphodiesterase inhibitor for the treatment of NAFLD, A randomized, placebo-controlled phase Ib/IIa trial.
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SUBMITTER: Hu Y
PROVIDER: S-EPMC10570369 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
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ZSP1601, a novel pan-phosphodiesterase inhibitor for the treatment of NAFLD, A randomized, placebo-controlled phase Ib/IIa trial.
Hu Yue Y Li Haijun H Zhang Hong H Chen Xiaoxin X Chen Jinjun J Xu Zhongyuan Z You Hong H Dong Ruihua R Peng Yun Y Li Jing J Li Xiaojiao X Wu Dandan D Zhang Lei L Cao Di D Jin He H Qiu Dongdong D Yang Aruhan A Lou Jinfeng J Zhu Xiaoxue X Niu Junqi J Ding Yanhua Y
Nature communications 20231012 1
Non-alcoholic fatty liver disease is a growing health burden with limited treatment options worldwide. Herein we report a randomized, double-blind, placebo-controlled, multiple-dose trial of a first-in-class pan-phosphodiesterase inhibitor ZSP1601 in 36 NAFLD patients (NCT04140123). There were three cohorts. Each cohort included twelve patients, nine of whom received ZSP1601 50 mg once daily, 50 mg twice daily, or 100 mg twice daily, and three of whom received matching placebos for 28 days. The ...[more]
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