Cottonseed oil alleviates ischemic stroke injury by inhibiting ferroptosis.

ABSTRACT:

Introduction

Ferroptosis has recently been recognized as a new cause of ischemia reperfusion injury due to blood-brain barrier (BBB) disruption followed by secondary iron-loaded transferrin (TF) influx. As a novel and independent cell death pathway, ferroptosis was characterized by iron-dependent lipid peroxidation, decline of GSH, GPX4, and shrinking mitochondria. Cottonseed oil (CSO), a liposoluble solvent, can alleviate ischemia stroke injuries and oxidative stress. However, the effect of CSO on ischemic stroke-induced ferroptosis has not been explored. In this study, we investigated the effect of CSO on ferroptosis caused by cerebral ischemic injury in rats.

Methods

We conducted the subcutaneous injection of 1.3 mL/kg CSO every other day for 3 weeks on rats with middle c

SUBMITTER: Sun M 

PROVIDER: S-EPMC10570467 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature