Enhanced rich club connectivity in mild or moderate depression after nonpharmacological treatment: A preliminary study.

ABSTRACT:

Introduction

It has been suggested that the rich club organization in major depressive disorder (MDD) was altered. However, it remained unclear whether the rich club organization could be served as a biomarker that predicted the improvement of clinical symptoms in MDD.

Methods

The current study included 29 mild or moderate patients with MDD, who were grouped into a treatment group (receiving cognitive behavioral therapy or real-time fMRI feedback treatment) and a no-treatment group. Resting-state MRI scans were obtained for all participants. Graph theory was employed to investigate the treatment-related changes in network properties and rich club organization.

Results

We found that patients in the treatment group had decreased depressive symptom scores and enhanced ri

SUBMITTER: Long Z 

PROVIDER: S-EPMC10570500 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature