Genetic determinants of Vitamin D deficiency in the Middle Eastern Qatari population: a genome-wide association study.

ABSTRACT:

Introduction

Epidemiological studies have consistently revealed that Vitamin D deficiency is most prevalent in Middle Eastern countries. However, research on the impact of genetic loci and polygenic models related to Vitamin D has primarily focused on European populations.

Methods

We conducted the first genome-wide association study to identify genetic determinants of Vitamin D levels in Middle Easterners using a whole genome sequencing approach in 6,047 subjects from the Qatar Biobank (QBB) project. We performed a GWAS meta-analysis, combining the QBB cohort with recent European GWAS data from the UK Biobank (involving 345,923 individuals). Additionally, we evaluated the performance of European-derived polygenic risk scores using UK Biobank data in the QBB cohort.

Result

SUBMITTER: Hendi NN 

PROVIDER: S-EPMC10570512 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature