Robust homeostasis of cellular cholesterol is a consequence of endogenous antithetic integral control.

ABSTRACT: Although cholesterol is essential for cellular viability and proliferation, it is highly toxic in excess. The concentration of cellular cholesterol must therefore be maintained within tight tolerances, and is thought to be subject to a stringent form of homeostasis known as Robust Perfect Adaptation (RPA). While much is known about the cellular signalling interactions involved in cholesterol regulation, the specific chemical reaction network structures that might be responsible for the robust homeostatic regulation of cellular cholesterol have been entirely unclear until now. In particular, the molecular mechanisms responsible for sensing excess whole-cell cholesterol levels have not been identified previously, and no mathematical models to date have been able to capture an integral contro

SUBMITTER: Scheepers R 

PROVIDER: S-EPMC10570530 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature