Stress mechanism involved in the progression of alcoholic liver disease and the therapeutic efficacy of nanoparticles.

ABSTRACT: Alcoholic liver disease (ALD) poses a significant threat to human health, with excessive alcohol intake disrupting the immunotolerant environment of the liver and initiating a cascade of pathological events. This progressive disease unfolds through fat deposition, proinflammatory cytokine upregulation, activation of hepatic stellate cells, and eventual development of end-stage liver disease, known as hepatocellular carcinoma (HCC). ALD is intricately intertwined with stress mechanisms such as oxidative stress mediated by reactive oxygen species, endoplasmic reticulum stress, and alcohol-induced gut dysbiosis, culminating in increased inflammation. While the initial stages of ALD can be reversible with diligent care and abstinence, further progression necessitates alternative treatment appr

SUBMITTER: Aghara H 

PROVIDER: S-EPMC10570533 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature