Unlocking the potential of 3D printed microfluidics for mass spectrometry analysis using liquid infused surfaces.

ABSTRACT: Combining microfluidics with mass spectrometry (MS) analysis has great potential for enabling new analytical applications and simplifying existing MS workflows. The rapid development of 3D printing technology has enabled direct fabrication of microfluidic channels using consumer grade 3D printers, which holds great promise to facilitate the adoption of microfluidic devices by the MS community. However, photo polymerization-based 3D printed devices have an issue with chemical leeching, which can introduce contaminant molecules that may present as isobaric ions and/or severely suppress the ionization of target analytes when combined with MS analysis. Although extra cure and washing steps have alleviated the leeching issue, many such contaminant peaks can still show up in mass spectra. In thi

SUBMITTER: Wang J 

PROVIDER: S-EPMC10570538 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature