Analysis of gut bacteriome of in utero arsenic-exposed mice using 16S rRNA-based metagenomic approach.

ABSTRACT:

Introduction

Approximately 200 million people worldwide are affected by arsenic toxicity emanating from the consumption of drinking water containing inorganic arsenic above the prescribed maximum contaminant level. The current investigation deals with the role of prenatal arsenic exposure in modulating the gut microbial community and functional pathways of the host.

Method

16S rRNA-based next-generation sequencing was carried out to understand the effects of in utero 0.04 mg/kg (LD) and 0.4 mg/kg (HD) of arsenic exposure. This was carried out from gestational day 15 (GD-15) until the birth of pups to understand the alterations in bacterial diversity.

Results

The study focused on gestational exposure to arsenic and the altered gut microbial community at phyla an

SUBMITTER: Shukla S 

PROVIDER: S-EPMC10570621 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature