The effect of estrogen therapy on cerebral metabolism in diabetic female rats.

ABSTRACT: The impact of estrogen on brain function, especially in individuals with diabetes, remains uncertain. This study aims to compare cerebral glucose metabolism levels in intact rats, ovariectomized (OVX) rats, and 17β-estradiol (E2)-treated OVX diabetic female rats. Sixteen rats were administered a single intraperitoneal injection of 70 mg/kg streptozotocin (STZ) to induce diabetes (intact, n = 6; OVX, n = 6; OVX+E2-treated, n = 4). Additionally, 18 rats received an equivalent solvent dose via intraperitoneal injection (intact, n = 6; OVX, n = 6; OVX+E2-treated, n = 6). After 4 weeks of STZ or solvent administration, positron emission tomography scans with ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) injection were employed to assess cerebral glucose metabolism. The diabetic rats ex

SUBMITTER: Wu CY 

PROVIDER: S-EPMC10570627 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature