Spatial Profiling of Circular RNAs in Cancer Reveals High Expression in Muscle and Stromal Cells.

ABSTRACT: Circular RNAs (circRNA) are covalently closed molecules that can play important roles in cancer development and progression. Hundreds of differentially expressed circRNAs between tumors and adjacent normal tissues have been identified in studies using RNA sequencing or microarrays, emphasizing a strong translational potential. Most previous studies have been performed using RNA from bulk tissues and lack information on the spatial expression patterns of circRNAs. Here, we showed that the majority of differentially expressed circRNAs from bulk tissue analyses of colon tumors relative to adjacent normal tissues were surprisingly not differentially expressed when comparing cancer cells directly with normal epithelial cells. Manipulating the proliferation rates of cells grown in culture reveal

SUBMITTER: Garcia-Rodriguez JL 

PROVIDER: S-EPMC10570686 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature