Significance of aortoseptal angle anomalies to left ventricular hemodynamics and subaortic stenosis: A numerical study.

ABSTRACT:

Purpose

Discrete subaortic stenosis (DSS) is an obstructive cardiac disease caused by a membranous lesion in the left ventricular (LV) outflow tract (LVOT). Although its etiology is unknown, the higher prevalence of DSS in LVOT anatomies featuring a steep aortoseptal angle (AoSA) suggests a potential role for hemodynamics. Therefore, the objective of this study was to quantify the impact of AoSA steepening on the LV three-dimensional (3D) hemodynamic stress environment.

Methods

A 3D LV model reconstructed from cardiac cine-magnetic resonance imaging was connected to four LVOT geometrical variations spanning the clinical AoSA range (115°-160°). LV hemodynamic stresses were characterized in terms of cycle-averaged pressure, temporal shear magnitude (TSM), and oscillatory shear

SUBMITTER: Shar JA 

PROVIDER: S-EPMC10570849 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature