Haematopoietic cell-derived exosomes in cancer development and therapeutics: From basic science to clinical practice.

ABSTRACT:

Background

The tumour microenvironment (TME) is a specialised niche involving intercellular communication among cancer cells and various host cells. Among the host cells, the quantity and quality of immune cells within the TME play essential roles in cancer development and management. The immunologically suppressive, so-called 'cold' TME established by a series of tumour-host interactions, including generating immunosuppressive cytokines and recruiting regulatory host immune cells, is associated with resistance to therapies and worse clinical outcomes.

Main body

Various therapeutic approaches have been used to target the cold TME, including immune checkpoint blockade therapy and adoptive T-cell transfer. A promising, less explored therapeutic strategy involves targeting TME-

SUBMITTER: Lin WC 

PROVIDER: S-EPMC10571015 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature