VEO-IBD NOX1 variant highlights a structural region essential for NOX/DUOX catalytic activity.

ABSTRACT: Inflammatory bowel diseases (IBD) are chronic intestinal disorders that result from an inappropriate inflammatory response to the microbiota in genetically susceptible individuals, often triggered by environmental stressors. Part of this response is the persistent inflammation and tissue injury associated with deficiency or excess of reactive oxygen species (ROS). The NADPH oxidase NOX1 is highly expressed in the intestinal epithelium, and inactivating NOX1 missense mutations are considered a risk factor for developing very early onset IBD. Albeit NOX1 has been linked to wound healing and host defence, many questions remain about its role in intestinal homeostasis and acute inflammatory conditions. Here, we used in vivo imaging in combination with inhibitor studies and germ-free conditions

SUBMITTER: Ward J 

PROVIDER: S-EPMC10571032 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature