Harnessing the value of TCTP in breast cancer treatment resistance: an opportunity for personalized therapy.

ABSTRACT: Early identification of breast cancer (BC) patients at a high risk of progression may aid in therapeutic and prognostic aims. This is especially true for metastatic disease, which is responsible for most cancer-related deaths. Growing evidence indicates that the translationally controlled tumor protein (TCTP) may be a clinically relevant marker for identifying poorly differentiated aggressive BC tumors. TCTP is an intriguing protein with pleiotropic functions, which is involved in multiple signaling pathways. TCTP may also be involved in stress response, cell growth and proliferation-related processes, underlying its potential role in the initiation of metastatic growth. Thus, TCTP marks specific cancer cell sub-populations with pronounced stress adaptation, stem-like and immune-evasive pr

SUBMITTER: Santamaria G 

PROVIDER: S-EPMC10571059 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature