Synthesis of sulfonyl 2-aryl-5-methylenyltetrahydropyrans.

ABSTRACT: In this study, the present research describes a high-yield method for the synthesis of sulfonyl 2-aryl-5-methylenetetrahydropyrans by one-pot straightforward DABCO-promoted intramolecular Michael addition of β-sulfonyl styrene with 2-chloromethyl-1-propenol followed by intramolecular alkylation. This Baylis-Hillman-type pathway provides a highly effective stereoselective annulation by forming one carbon-oxygen bond and one carbon-carbon bond.

SUBMITTER: Chang MY 

PROVIDER: S-EPMC10571095 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature