MCCC2 is a novel mediator between mitochondria and telomere and functions as an oncogene in colorectal cancer.

ABSTRACT:

Background

The mitochondrial gene MCCC2, a subunit of the heterodimer of 3-methylcrotonyl-CoA carboxylase, plays a pivotal role in catabolism of leucine and isovaleric acid. The molecular mechanisms and prognostic value still need to be explored in the context of specific cancers, including colorectal cancer (CRC).

Methods

In vitro and in vivo cell-based assays were performed to explore the role of MCCC2 in CRC cell proliferation, invasion, and migration. Mitochondrial morphology, membrane potential, intracellular reactive oxygen species (ROS), telomerase activity, and telomere length were examined and analyzed accordingly. Protein complex formation was detected by co-immunoprecipitation (CO-IP). Mitochondrial morphology was observed by transmission electron microscopy (TEM)

SUBMITTER: Liu W 

PROVIDER: S-EPMC10571261 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature