Nailfold capillary density in 140 untreated children with juvenile dermatomyositis: an indicator of disease activity.

ABSTRACT:

Background

We lack a reliable indicator of disease activity in Juvenile Dermatomyositis (JDM), a rare disease. The goal of this study is to identify the association of nailfold capillary End Row Loop (ERL) loss with disease damage in children with newly diagnosed, untreated JDM.

Findings

We enrolled 140 untreated JDM and 46 age, race and sex matched healthy controls, ages 2-17. We selected items from the Juvenile Myositis Registry for analysis. Variables include average ERL density of 8 fingers, average capillary pattern, hemorrhages, and clinical and laboratory correlates. Laboratory data includes Myositis Specific Antibodies (MSA), disease activity scores (DAS), Childhood Myositis Assessment Scale (CMAS), and standard clinical serologic data. The reduced mean ERL density i

SUBMITTER: Pachman LM 

PROVIDER: S-EPMC10571265 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature