Neocortex neurogenesis and maturation in the African greater cane rat.

ABSTRACT:

Background

Neocortex development has been extensively studied in altricial rodents such as mouse and rat. Identification of alternative animal models along the "altricial-precocial" spectrum in order to better model and understand neocortex development is warranted. The Greater cane rat (GCR, Thyronomys swinderianus) is an indigenous precocial African rodent. Although basic aspects of brain development in the GCR have been documented, detailed information on neocortex development including the occurrence and abundance of the distinct types of neural progenitor cells (NPCs) in the GCR are lacking.

Methods

GCR embryos and fetuses were obtained from timed pregnant dams between gestation days 50-140 and their neocortex was analyzed by immunofluorescence staining using characteri

SUBMITTER: Mustapha O 

PROVIDER: S-EPMC10571270 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature