The serum lipid profiles in immune thrombocytopenia: Mendelian randomization analysis and a retrospective study.

ABSTRACT:

Background

Immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease characterized by increased platelet destruction and impaired thrombopoiesis. The changes in platelet indices depend on the morphology and volume of platelets. Serum lipids have been found to affect platelet formation and activity in certain diseases, thus inducing the corresponding variation of platelet indices.

Methods

Mendelian randomization (MR) analysis was performed based on databases. The clinical data from 457 ITP patients were retrospectively collected and analyzed, including platelet indices, serum lipids, hemorrhages and therapeutic responses.

Results

MR analysis showed low high-density-lipoprotein-cholesterol (HDL-C), low apolipoprotein A-1, high triglyceride (TG) and high apolipo

SUBMITTER: Xu P 

PROVIDER: S-EPMC10571271 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature