Identification of the causal relationship between sleep quality, insomnia, and oral ulcers.

ABSTRACT:

Background

Multiple epidemiological studies have posited a potential association between sleep quality and the risk of oral diseases, yet the resulting conclusions have remained contentious, and the presence of a causal link remains equivocal. In this study, we aimed to investigate the causal relationship between sleep duration, insomnia, and common oral diseases.

Methods

We utilized genetic correlation and two-sample Mendelian randomization analyses based on summary statistics from genome-wide association studies of sleep duration (N = 460,099), insomnia (N = 462,341), mouth ulcer (N = 385,026), oral cavity cancer (N = 4,151), and periodontal disease (N = 527,652).

Results

Our results revealed a negative genetic correlation between sleep duration and mouth ulcer (gen

SUBMITTER: Liu Q 

PROVIDER: S-EPMC10571295 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature