Blood biomarkers and neurodegeneration in individuals exposed to repetitive head impacts.

ABSTRACT:

Background

It is unknown if fluid biomarkers reflective of brain pathologies are useful in detecting and following a neurodegenerative process in individuals exposed to repetitive head impacts. This study explores the relationship between blood biomarkers and longitudinal change in cognitive function and regional brain volumes in a cohort of professional fighters.

Methods

Participants are drawn from a convenience sample of active and retired professional boxers and Mixed Martial Arts fighters and a control group with no prior exposure to head impacts. 3 T MRI brain imaging, plasma samples, and computerized cognitive testing were obtained at baseline and, for a subset, annually. MRI regional volumes were extracted, along with plasma levels of neurofilament light chain (NfL),

SUBMITTER: Bernick C 

PROVIDER: S-EPMC10571311 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature