CanISO: a database of genomic and transcriptomic variations in domestic dog (Canis lupus familiaris).

ABSTRACT:

Background

The domestic dog, Canis lupus familiaris, is a companion animal for humans as well as an animal model in cancer research due to similar spontaneous occurrence of cancers as humans. Despite the social and biological importance of dogs, the catalogue of genomic variations and transcripts for dogs is relatively incomplete.

Results

We developed CanISO, a new database to hold a large collection of transcriptome profiles and genomic variations for domestic dogs. CanISO provides 87,692 novel transcript isoforms and 60,992 known isoforms from whole transcriptome sequencing of canine tumors (N = 157) and their matched normal tissues (N = 64). CanISO also provides genomic variation information for 210,444 unique germline single nucleotide polymorphisms (SNPs) from the whole

SUBMITTER: Yang IS 

PROVIDER: S-EPMC10571338 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature