Origin recognition complex subunit 1(ORC1) is a potential biomarker and therapeutic target in cancer.

ABSTRACT:

Background

The origin recognition complex 1 (ORC1) is a large subunit of the origin recognition complex and acts as the master subunit of the precoding complex.

Objective

To explore potential function and clinical significance of ORC1 in cancers.

Methods

The expression level of ORC1 in different types of tumor tissues and matched normal tissues were detected by The Cancer Genome Atlas (TCGA) and validated by datasets from the gene expression omnibus (GEO) database. The association between ORC1 expression and infiltration levels of immune cell was analyzed. ORC1 and its co-expression genes were subjected to enrichment analysis to explore potential mechanisms in cancers, and the protein-protein interaction (PPI) network was constructed. Finally, the expression of ORC1 i

SUBMITTER: Wu L 

PROVIDER: S-EPMC10571394 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature