High expression of CCDC69 is correlated with immunotherapy response and protective effects on breast cancer.

ABSTRACT:

Background

As a molecule controlling the assembly of central spindles and recruitment of midzone component, coiled-coil domain-containing protein 69 (CCDC69) plays an important role in multiple cancers. Currently, the relationships between CCDC69 and immune infiltration or immunotherapy in breast cancer remain unclear.

Methods

The expression and prognostic significance of CCDC69 in breast cancer were comprehensively analyzed by quantitative real-time PCR, immunohistochemical staining and various databases. The data source of differentially expressed genes, gene set enrichment analysis, and immune cell infiltration analysis came from The Cancer Genome Atlas (TCGA) database. Single-cell analysis based on IMMUcan database was used. The protein-protein interaction network was de

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10571395 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature