N⁶-methyladenosine modification-a key player in viral infection.

ABSTRACT: N⁶-methyladenosine (m⁶A) modification is a dynamic, reversible process and is the most prevalent internal modification of RNA. This modification is regulated by three protein groups: methyltransferases ("writers"), demethylases ("erasers"), and m⁶A-binding proteins ("readers"). m⁶A modification and related enzymes could represent an optimal strategy to deepen the epigenetic mechanism. Numerous reports have suggested that aberrant modifications of m⁶A lead to aberrant expression of important viral genes. Here, we review the role of m⁶A modifications in viral replication and virus-host interactions. In particular, we focus on DNA and RNA viruses associated with human diseases, such as severe acute respiratory syndrome coronavi

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10571408 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature