Cortical glutamatergic projection neuron types contribute to distinct functional subnetworks.

ABSTRACT: The cellular basis of cerebral cortex functional architecture remains not well understood. A major challenge is to monitor and decipher neural network dynamics across broad cortical areas yet with projection-neuron-type resolution in real time during behavior. Combining genetic targeting and wide-field imaging, we monitored activity dynamics of subcortical-projecting (PT^Fezf2) and intratelencephalic-projecting (IT^PlxnD1) types across dorsal cortex of mice during different brain states and behaviors. IT^PlxnD1 and PT^Fezf2 neurons showed distinct activation patterns during wakeful resting, during spontaneous movements and upon sensory stimulation. Distinct IT^PlxnD1 and PT^Fezf2 subnetworks were dynamically tuned to different sen

SUBMITTER: Mohan H 

PROVIDER: S-EPMC10571488 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature