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Pancreatic Cancer-Secreted Proteins: Targeting Their Functions in Tumor Microenvironment.

ABSTRACT: Pancreatic Ductal Adenocarcinoma (PDAC) is a ravaging disease with a poor prognosis, requiring a more detailed understanding of its biology to foster the development of effective therapies. The unsatisfactory results of treatments targeting cell proliferation and its related mechanisms suggest a shift in focus towards the inflammatory tumor microenvironment (TME). Here, we discuss the role of cancer-secreted proteins in the complex TME tumor-stroma crosstalk, shedding lights on druggable molecular targets for the development of innovative, safer and more efficient therapeutic strategies.

SUBMITTER: Cammarota AL

PROVIDER: S-EPMC10571538 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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Pancreatic Cancer-Secreted Proteins: Targeting Their Functions in Tumor Microenvironment.

Cammarota Anna Lisa AL Falco Antonia A Basile Anna A Molino Carlo C Chetta Massimiliano M D'Angelo Gianni G Marzullo Liberato L De Marco Margot M Turco Maria Caterina MC Rosati Alessandra A

Cancers 20231001 19

Pancreatic Ductal Adenocarcinoma (PDAC) is a ravaging disease with a poor prognosis, requiring a more detailed understanding of its biology to foster the development of effective therapies. The unsatisfactory results of treatments targeting cell proliferation and its related mechanisms suggest a shift in focus towards the inflammatory tumor microenvironment (TME). Here, we discuss the role of cancer-secreted proteins in the complex TME tumor-stroma crosstalk, shedding lights on druggable molecul ...[more]

PMID: 37835519

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