Decanoic Acid Exerts Its Anti-Tumor Effects via Targeting c-Met Signaling Cascades in Hepatocellular Carcinoma Model.
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ABSTRACT:
SUBMITTER: Yang MH
PROVIDER: S-EPMC10571573 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
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Decanoic Acid Exerts Its Anti-Tumor Effects via Targeting c-Met Signaling Cascades in Hepatocellular Carcinoma Model.
Yang Min Hee MH Lee Mina M Deivasigamani Amudha A Le Duc Dat DD Mohan Chakrabhavi Dhananjaya CD Hui Kam Man KM Sethi Gautam G Ahn Kwang Seok KS
Cancers 20230922 19
DA, one of the medium-chain fatty acids found in coconut oil, is suggested to have diverse biochemical functions. However, its possible role as a chemoprevention agent in HCC has not been deciphered. Aberrant activation of c-Met can modulate tumor growth and progression in HCC. Here, we report that DA exhibited pro-found anti-tumor effects on human HCC through the suppression of HGF/c-Met signaling cascades in vitro and in vivo. It was noted that DA inhibited HGF-induced activation of c-Met and ...[more]
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