Selective Activation of M₁ Muscarinic Receptors Attenuates Human Colon Cancer Cell Proliferation.

ABSTRACT: M₃ muscarinic receptor (M₃R) activation stimulates colon cancer cell proliferation, migration, and invasion; M₃R expression is augmented in colon cancer and ablating M₃R expression in mice attenuates colon neoplasia. Several lines of investigation suggest that in contrast to these pro-neoplastic effects of M₃R, M₁R plays an opposite role, protecting colon epithelial cells against neoplastic transformation. To pursue these intriguing findings, we examined the relative expression of M₁R versus M₃R in progressive stages of colon neoplasia and the effect of treating colon cancer cells with selective M₁R agonists. We detected divergent expression of M₁R and M₃R in progressive

SUBMITTER: Sundel MH 

PROVIDER: S-EPMC10571583 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature