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Elrexfio™ (elranatamab-bcmm): The game-changer in treatment of multiple myeloma.

ABSTRACT: Multiple myeloma is the second most common plasma cell malignancy, characterized by uncontrolled proliferation of plasma cells within the bone marrow. ELREXFIO™ (elranatamab-bcmm) is a recently FDA-approved drug for relapsed and refractory multiple myeloma. The progression of multiple myeloma involves interactions with various bone marrow cell types, and targeting this microenvironment has shown promising results in inhibiting its growth and osteolysis. ELREXFIO, a bispecific antibody targeting CD3 and BCMA, activates cytotoxic T-lymphocyte responses against BCMA-expressing myeloma cells. Clinical trials, such as MagnetisMM-3, demonstrated significant response rates and long-term tolerability. Its approval offers hope to multiple myeloma patients, especially those with relapsed or refractory cases, as innovative therapies like ELREXFIO continue to improve outcomes in this challenging malignancy.

SUBMITTER: Rais T

PROVIDER: S-EPMC10571667 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Elrexfio™ (elranatamab-bcmm): The game-changer in treatment of multiple myeloma.

Rais Taruba T Khan Afsheen A Riaz Rumaisa R

Rare tumors 20231011

Multiple myeloma is the second most common plasma cell malignancy, characterized by uncontrolled proliferation of plasma cells within the bone marrow. ELREXFIO™ (elranatamab-bcmm) is a recently FDA-approved drug for relapsed and refractory multiple myeloma. The progression of multiple myeloma involves interactions with various bone marrow cell types, and targeting this microenvironment has shown promising results in inhibiting its growth and osteolysis. ELREXFIO, a bispecific antibody targeting ...[more]

PMID: 37840703

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Elranatamab in relapsed or refractory multiple myeloma: the MagnetisMM-1 phase 1 trial.

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Elranatamab in Japanese patients with relapsed/refractory multiple myeloma: results from MagnetisMM-2 and MagnetisMM-3.

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