Modulation of gut microbiota: a novel approach to enhancing the effects of immune checkpoint inhibitors.

ABSTRACT: Although immune checkpoint inhibitors (ICIs) have greatly improved the prognosis of some cancer patients, the majority still fail to respond adequately, and the available biomarkers cannot reliably predict drug efficacy. The gut microbiota has received widespread attention among the various intrinsic and extrinsic factors contributing to drug resistance. As an essential regulator of physiological function, the impact of gut microbiota on host immunity and response to cancer therapy is increasingly recognized. Several studies have demonstrated significant differences in gut microbiota between responders and nonresponders. The gut microbiota associated with better clinical outcomes is called 'favorable gut microbiota'. Significantly, interventions can alter the gut microbiota. By shifting th

SUBMITTER: Huang J 

PROVIDER: S-EPMC10571694 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature