MYCN Amplifications and Metabolic Rewiring in Neuroblastoma.

ABSTRACT: Cancer is a disease caused by (epi)genomic and gene expression abnormalities and characterized by metabolic phenotypes that are substantially different from the normal phenotypes of the tissues of origin. Metabolic reprogramming is one of the key features of tumors, including those established in the human nervous system. In this work, we emphasize a well-known cancerous genomic alteration: the amplification of MYCN and its downstream effects in neuroblastoma phenotype evolution. Herein, we extend our previous computational biology investigations by conducting an integrative workflow applied to published genomics datasets and comprehensively assess the impact of MYCN amplification in the upregulation of metabolism-related transcription factor (TF)-encoding genes in neuroblast

SUBMITTER: Pouliou M 

PROVIDER: S-EPMC10571721 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature