Reporting of 3Rs Approaches in Preclinical Animal Experimental Studies-A Nationwide Study.

ABSTRACT: The 3Rs aim to refine animal welfare, reduce animal numbers, and replace animal experiments. Investigations disclose that researchers are positive towards 3Rs recommendations from peers. Communication of 3Rs approaches via primary preclinical animal experimental literature may become a fast-forward extension to learn relevant 3Rs approaches if such are reported. This study investigates 3Rs-reporting in peer-reviewed preclinical animal research with at least one author affiliated to a Danish university. Using a systematic search and random sampling, we included 500 studies from 2009 and 2018. Reporting was low and improvement over time limited. A word search for 3R retrieved zero results in 2009 and 3.2% in 2018. Reporting on 3Rs-related sentences increased from 6.4% in 2009 to 18.4% in 201

SUBMITTER: Kousholt BS 

PROVIDER: S-EPMC10571812 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature