Linking Mechanisms of Vitamin D Signaling with Multiple Sclerosis.

ABSTRACT: Environmental triggers often work via signal transduction cascades that modulate the epigenome and transcriptome of cell types involved in the disease process. Multiple sclerosis (MS) is an autoimmune disease affecting the central nervous system being characterized by a combination of recurring inflammation, demyelination and progressive loss of axons. The mechanisms of MS onset are not fully understood and genetic variants may explain only some 20% of the disease susceptibility. From the environmental factors being involved in disease development low vitamin D levels have been shown to significantly contribute to MS susceptibility. The pro-hormone vitamin D₃ acts via its metabolite 1α,25-dihydroxyvitamin D₃ (1,25(OH)₂D₃) as a high affinity ligan

SUBMITTER: Carlberg C 

PROVIDER: S-EPMC10571821 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature