Genome-Wide Characterization of TAZ Binding Sites in Mammary Epithelial Cells.

ABSTRACT: The transcriptional co-activator with PDZ binding motif (TAZ) is a key effector of the Hippo signaling pathway. We and others previously reported that high expression levels of TAZ are positively associated with decreased survival rates and shorter times to relapse in basal-like breast cancer (BLBC) patients. The oncogenic activity of TAZ involves the regulation of diverse signal transduction pathways that direct processes such as cell proliferation, migration, and resistance to apoptosis, albeit through poorly characterized gene expression programs. Here, using a tet-inducible system in mammary epithelial MCF10A cells, we have characterized the TAZ-regulated transcription program using RNA sequencing in a temporal and spatial manner. We further identified global TAZ binding sites at diffe

SUBMITTER: Liu T 

PROVIDER: S-EPMC10571831 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature