The Potential of Hormonal Therapies for Treatment of Triple-Negative Breast Cancer.

ABSTRACT: Triple-negative breast cancer (TNBC) is considered one of the most aggressive forms of breast cancer with poor survival rates compared to other breast cancer subtypes. TNBC is characterized by the absence of the estrogen receptor alpha, progesterone receptor, and the human epidermal growth factor receptor 2, limiting those viable treatment options available to patients with other breast cancer subtypes. Furthermore, due to the particularly high heterogeneity of TNBC, conventional treatments such as chemotherapy are not universally effective, leading to drug resistance and intolerable side effects. Thus, there is a pressing need to discover new therapies beneficial to TNBC patients. This review highlights current findings regarding the roles of three steroid hormone receptors, estrogen rece

SUBMITTER: Kirkby M 

PROVIDER: S-EPMC10571841 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature