RAGE as a Novel Biomarker for Prostate Cancer: A Systematic Review and Meta-Analysis.

ABSTRACT: The receptor for advanced glycation end-products (RAGE) has been implicated in driving prostate cancer (PCa) growth, aggression, and metastasis through the fueling of chronic inflammation in the tumor microenvironment. This systematic review and meta-analysis summarizes and analyzes the current clinical and preclinical data to provide insight into the relationships among RAGE levels and PCa, cancer grade, and molecular effects. A multi-database search was used to identify original clinical and preclinical research articles examining RAGE expression in PCa. After screening and review, nine clinical and six preclinical articles were included. The associations of RAGE differentiating benign prostate hyperplasia (BPH) or normal prostate from PCa and between tumor grades were estimated using od

SUBMITTER: Applegate CC 

PROVIDER: S-EPMC10571903 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature