The Role of Non-Coding RNAs in Myelodysplastic Neoplasms.

ABSTRACT: Myelodysplastic syndromes or neoplasms (MDS) are a heterogeneous group of myeloid clonal disorders characterized by peripheral blood cytopenias, blood and marrow cell dysplasia, and increased risk of evolution to acute myeloid leukemia (AML). Non-coding RNAs, especially microRNAs and long non-coding RNAs, serve as regulators of normal and malignant hematopoiesis and have been implicated in carcinogenesis. This review presents a comprehensive summary of the biology and role of non-coding RNAs, including the less studied circRNA, siRNA, piRNA, and snoRNA as potential prognostic and/or predictive biomarkers or therapeutic targets in MDS.

SUBMITTER: Georgoulis V 

PROVIDER: S-EPMC10571949 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature