Multi-Functional Regulation by YAP/TAZ Signaling Networks in Tumor Progression and Metastasis.

ABSTRACT: The Hippo pathway transcriptional co-activators, YES-associated protein (YAP) and Transcriptional Co-Activator with PDZ Binding Motif (TAZ), have both been linked to tumor progression and metastasis. These two proteins possess overlapping and distinct functions, and their activities lead to the expression of genes involved in multiple cellular processes, including cell proliferation, survival, and migration. The dysregulation of YAP/TAZ-dependent cellular processes can result in altered tumor growth and metastasis. In addition to their well-documented roles in the regulation of cancer cell growth, survival, migration, and invasion, the YAP/TAZ-dependent signaling pathways have been more recently implicated in cellular processes that promote metastasis and therapy resistance in several soli

SUBMITTER: Thrash HL 

PROVIDER: S-EPMC10572014 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature