Methamphetamine alters nucleus accumbens neural activation to monetary loss in healthy young adults.

ABSTRACT:

Rationale

Stimulant drugs like methamphetamine (MA) activate brain reward circuitry, which is linked to the development of problematic drug use. It is not clear how drugs like MA alter neural response to a non-drug reward.

Objectives

We examined how acute MA impacts neural response to receipt of a monetary reward relative to a loss in healthy adults. We hypothesized that MA (vs. placebo) would increase mesolimbic neural activation to reward, relative to loss.

Methods

In a within-subject, randomized, cross-over, double-blind, placebo-controlled design, 41 healthy adults completed the Doors monetary reward task during fMRI after ingestion of placebo or 20 mg MA. We examined drug effects on neural response to reward receipt (Win vs. Loss) using a priori anatomical striat

SUBMITTER: Crane NA 

PROVIDER: S-EPMC10572040 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature