Ontology highlight
ABSTRACT:
SUBMITTER: Miziak P
PROVIDER: S-EPMC10572081 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Miziak Paulina P Baran Marzena M Błaszczak Ewa E Przybyszewska-Podstawka Alicja A Kałafut Joanna J Smok-Kalwat Jolanta J Dmoszyńska-Graniczka Magdalena M Kiełbus Michał M Stepulak Andrzej A
Cancers 20230923 19
Estrogen receptor (ER) signaling is a critical regulator of cell proliferation, differentiation, and survival in breast cancer (BC) and other hormone-sensitive cancers. In this review, we explore the mechanism of ER-dependent downstream signaling in BC and the role of estrogens as growth factors necessary for cancer invasion and dissemination. The significance of the clinical implications of ER signaling in BC, including the potential of endocrine therapies that target estrogens' synthesis and E ...[more]