A Novel tRNA-Derived Fragment, tRF^GlnCTG, Regulates Angiogenesis by Targeting Antxr1 mRNA.

ABSTRACT: As a novel non-coding RNA with important functions corresponding to various cellular stresses, the function of tRFs in angiogenesis remains unclear. Firstly, small RNA sequencing was performed on normal and post-muscle injury mouse tibialis anterior muscle to identify and analyse differentially expressed tRF/tiRNA. tRNA GlnCTG-derived fragments (tRF^GlnCTG) were found to be overexpressed in high abundance in the damaged muscle. Subsequent in vitro experiments revealed that the overexpression of tRF^GlnCTG suppressed the vascular endothelial cells' viability, cell cycle G1/S transition, proliferation, migration, and tube-formation capacity. Similarly, in vivo experiments showed that the tRF^GlnCTG decreased the relative mRNA levels of vascular endothelial cell

SUBMITTER: Chen Q 

PROVIDER: S-EPMC10572189 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature