BFGF-like Activity Supported Tissue Regeneration, Modulated Neuroinflammation, and Rebalanced Ca²⁺ Homeostasis following Spinal Cord Injury.

ABSTRACT: A spinal cord injury (SCI) is a well-defined debilitating traumatic event to the spinal cord that usually triggers permanent changes in motor, sensory, and autonomic functions. Injured tissue becomes susceptible to secondary mechanisms caused by SCIs, which include pro-inflammatory cytokine release, the activation of astrocytes and microglia, and increased neuronal sensibility. As a consequence, the production of factors such as GFAP, IBA-1, TNF-α, IL-1β, IFN-γ, and S100-β slow down or inhibit central nervous system (CNS) regeneration. In this regard, a thorough understanding of the mechanisms regulating the CNS, and specifically SCI, is essential for the development of new therapeutic strategies. It has been demonstrated that basic fibroblast growth factor (bFGF) was successful in the mod

SUBMITTER: Ardizzone A 

PROVIDER: S-EPMC10572408 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature