Ketogenic Diet Affects Sleep Architecture in C57BL/6J Wild Type and Fragile X Mice.

ABSTRACT: Nearly half of children with fragile X syndrome experience sleep problems including trouble falling asleep and frequent nighttime awakenings. The goals here were to assess sleep-wake cycles in mice in response to Fmr1 genotype and a dietary intervention that reduces hyperactivity. Electroencephalography (EEG) results were compared with published rest-activity patterns to determine if actigraphy is a viable surrogate for sleep EEG. Specifically, sleep-wake patterns in adult wild type and Fmr1^KO littermate mice were recorded after EEG electrode implantation and the recordings manually scored for vigilance states. The data indicated that Fmr1^KO mice exhibited sleep-wake patterns similar to wild type littermates when maintained on a control purified i

SUBMITTER: Westmark PR 

PROVIDER: S-EPMC10572443 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature